Peer-reviewed publications from the Moore Lab
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2026
Striatal Neuron Excitability Is Regulated by Huntingtin in the Adult Brain Barron JC, Greenland ML, Carew SJ, Ashrafganjoie F, Hurley EP, Kennedy CM, Nafar F, Moore CS, Parsons MP · eNeuro · 2026 · PubMed
Bruton’s Tyrosine Kinase — Going Beyond the B Cell Benoit RY, Loshi S, Moore CS · Immunology · 2026 · PubMed
Best Practice Recommendations for Laboratory Analysis and Reporting of Cerebrospinal Fluid Oligoclonal Banding in MS Higgins V, Parker ML, Ahmed B, et al. · Clin Biochem · 2026 · PubMed
2025
Cerebrospinal Fluid-Driven Ependymal Motile Cilia Defects Are Implicated in Multiple Sclerosis Bigotte M, Groh AMR, Afanasiev E, et al. · Brain · 2025 · PubMed
MiR-146b-5p Decreases Cytokine Release From Astrocytes and Preserves Oligodendrocyte Progenitor Cell Complexity During Inflammation Thompson CE, Loshi S, Carew SJ, Berry TR, Parsons MP, Antel JP, Moore CS · Eur J Neurosci · 2025 · PubMed
From Cellular Waste to Biomarkers; Insights into Extracellular Vesicles Using Flow Cytometry Zagrodnik JL, Moore CS · J Pharmacol Toxicol Methods · 2025 · PubMed
Monocyte-Secreted Wnt Reduces the Efficiency of Central Nervous System Remyelination Hill BM, Holloway RK, Forbes LH, et al. · PLoS Biol · 2025 · PubMed
An Overview of Multiple Sclerosis Care in Rural and Urban Newfoundland and Labrador Fifield KE, Fudge NJ, Arsenault ST, et al. · Can J Neurol Sci · 2025 · PubMed
Huntingtin Plays an Essential Role in the Adult Hippocampus Barron JC, Dawson LJ, Carew SJ, et al. · Neurobiol Dis · 2025 · PubMed
Investigating T-Cell-Derived Extracellular Vesicles as Biomarkers of Disease Activity, Axonal Injury, and Disability in Multiple Sclerosis Zagrodnik JL, Blandford SN, Fudge NJ, et al. · Clin Exp Immunol · 2025 · PubMed
2024
A miR-383-5p Signaling Hub Coordinates the Axon Regeneration Response to Inflammation Hintermayer MA, Juźwik CA, Morquette B, et al. · J Neurosci · 2024 · PubMed
Bruton Tyrosine Kinase Inhibition Decreases Inflammation and Differentially Impacts Phagocytosis and Cellular Metabolism in Myeloid Cells Benoit RY, Zagrodnik JL, Carew SJ, Moore CS · Immunohorizons · 2024 · PubMed
Myelin-Reactive B Cells Exacerbate CD4+ T Cell-Driven CNS Autoimmunity in an IL-23-Dependent Manner Fazazi MR, Doss PMIA, Pereira R, et al. · Nat Commun · 2024 · PubMed
Transcranial Magnetic Stimulation Enhances the Specificity of Multiple Sclerosis Diagnostic Criteria Snow NJ, Murphy HM, Chaves AR, Moore CS, Ploughman M · PeerJ · 2024 · PubMed
Apically Localized PANX1 Impacts Neuroepithelial Expansion in Human Cerebral Organoids Noort RJ, Zhu H, Flemmer RT, Moore CS, Belbin TJ, Esseltine JL · Cell Death Discov · 2024 · PubMed
2023
Cross-Talk Between B Cells, Microglia and Macrophages, and Implications to CNS Compartmentalized Inflammation and Progressive MS Touil H, Li R, Zuroff L, et al. · EBioMedicine · 2023 · PubMed
Epstein Barr Virus and Multiple Sclerosis: Is a Cure Possible? Benoit RY, Moore CS · Viral Immunol · 2023 · PubMed
Translocator Protein Is a Marker of Activated Microglia in Rodent Models but Not Human Neurodegenerative Diseases Nutma E, Fancy N, Weinert M, et al. · Nat Commun · 2023 · PubMed
CXCL10 Is Associated with Increased Cerebrospinal Fluid Immune Cell Infiltration and Disease Duration in Multiple Sclerosis Blandford SN, Fudge NJ, Moore CS · Biomolecules · 2023 · PubMed
TAAR1 Regulates Purinergic-Induced TNF Secretion from Peripheral, But Not CNS-Resident, Macrophages Barnes DA, Hoener MC, Moore CS, Berry MD · J Neuroimmune Pharmacol · 2023 · PubMed
2022
Does the Use of Bruton Tyrosine Kinase Inhibitors and Masitinib Result in Clinically Significant Outcomes in Multiple Sclerosis? Arsenault S, Benoit RY, Clift F, Moore CS · Mult Scler Relat Disord · 2022 · PubMed
Investigating the NLRP3 Inflammasome and Its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination Galloway DA, Carew SJ, Blandford SN, et al. · J Neurochem · 2022 · PubMed
Analysis of Plasma Using Flow Cytometry Reveals Increased Immune Cell-Derived Extracellular Vesicles in Untreated RRMS Blandford SN, Fudge NJ, Corkum CP, Moore CS · Front Immunol · 2022 · PubMed
2021
TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation Barnes DA, Galloway DA, Hoener MC, Berry MD, Moore CS · Int J Mol Sci · 2021 · PubMed
Interleukin-1 Receptor Antagonist: An Exploratory Plasma Biomarker in Relapsing-Remitting Multiple Sclerosis Blandford SN, Galloway DA, Williams JB, et al. · Mult Scler Relat Disord · 2021 · PubMed
Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair in Progressive Multiple Sclerosis Devasahayam AJ, Kelly LP, Williams JB, Moore CS, Ploughman M · Biomolecules · 2021 · PubMed
Male Sex Chromosomal Complement Exacerbates the Pathogenicity of Th17 Cells in CNS Autoimmunity Doss PMIA, Umair M, Baillargeon J, et al. · Cell Rep · 2021 · PubMed
Pro-Inflammatory Adiponectin in Pediatric-Onset Multiple Sclerosis Nyirenda MH, Fadda G, Healy LM, et al. · Mult Scler · 2021 · PubMed
2020
Vigorous Cool Room Treadmill Training to Improve Walking Ability in People with MS: A Feasibility Study Devasahayam AJ, Chaves AR, Lasisi WO, et al. · BMC Neurol · 2020 · PubMed
2019
microRNA Dysregulation in Neurodegenerative Diseases: A Systematic Review Juźwik CA, Drake SS, Zhang Y, et al. · Prog Neurobiol · 2019 · PubMed
Phagocytosis in the Brain: Homeostasis and Disease Galloway DA, Phillips AEM, Owen DRJ, Moore CS · Front Immunol · 2019 · PubMed
Abnormal Effector and Regulatory T Cell Subsets in Paediatric-Onset Multiple Sclerosis Mexhitaj I, Nyirenda MH, Li R, et al. · Brain · 2019 · PubMed
Synergistic Benefits of Combined Aerobic and Cognitive Training on Fluid Intelligence and IGF-1 in Chronic Stroke Ploughman M, Eskes GA, Kelly LP, et al. · Neurorehabil Neural Repair · 2019 · PubMed
Prolonged Cortical Silent Period Is Related to Poor Fitness and Fatigue in Multiple Sclerosis Chaves AR, Kelly LP, Moore CS, Stefanelli M, Ploughman M · Clin Neurophysiol · 2019 · PubMed
miR-223 Promotes Regenerative Myeloid Cell Phenotype and Function in the Demyelinated CNS Galloway DA, Blandford SN, Berry T, et al. · Glia · 2019 · PubMed
Asymmetry of Brain Excitability: A New Biomarker in Multiple Sclerosis Chaves AR, Wallack EM, Kelly LP, et al. · Behav Brain Res · 2019 · PubMed
2018
The Roles of Extracellular Vesicle microRNAs in the Central Nervous System Blandford SN, Galloway DA, Moore CS · Glia · 2018 · PubMed
Human CNS Astrocytes Support Survival and Activation of B Cells: Implications for MS Pathogenesis Touil H, Kobert A, Lebeurrier N, et al. · J Neuroinflammation · 2018 · PubMed
Differential Transcriptional Response Profiles in Human Myeloid Cell Populations Healy LM, Perron G, Won SY, et al. · Clin Immunol · 2018 · PubMed
2017
α7 Nicotinic Acetylcholine Receptor Signaling Modulates Inflammatory Phenotype of Fetal Brain Microglia Cortes M, Cao M, Liu HL, et al. · Sci Rep · 2017 · PubMed
A Highly Efficient Human Pluripotent Stem Cell Microglia Model Haenseler W, Sansom SN, Buchrieser J, et al. · Stem Cell Reports · 2017 · PubMed
Comparative Morphology and Phagocytic Capacity of Primary Human Adult Microglia Levtova N, Healy LM, Gonczi CMC, et al. · J Neuroimmunol · 2017 · PubMed
Pro-Inflammatory Activation of Primary Microglia and Macrophages Increases 18 kDa Translocator Protein Expression Owen DR, Narayan N, Wells L, et al. · J Cereb Blood Flow Metab · 2017 · PubMed
Effects of Fumarates on Inflammatory Human Astrocyte Responses and Oligodendrocyte Differentiation Galloway DA, Williams JB, Moore CS · Ann Clin Transl Neurol · 2017 · PubMed
RNAseq Profiling of Primary Microglia and Astrocyte Cultures in Near-Term Ovine Fetus Cortes M, Cao M, Liu HL, et al. · J Neurosci Methods · 2017 · PubMed
2016
miRNAs As Emerging Regulators of Oligodendrocyte Development and Differentiation Galloway DA, Moore CS · Front Cell Dev Biol · 2016 · PubMed
Astrocytes in Multiple Sclerosis Ludwin SK, Rao VTs, Moore CS, Antel JP · Mult Scler · 2016 · PubMed
MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells Healy LM, Perron G, Won SY, et al. · J Immunol · 2016 · PubMed
MicroRNA Expression Patterns in Human Astrocytes in Relation to Anatomical Location and Age Rao VT, Ludwin SK, Fuh SC, et al. · J Neuropathol Exp Neurol · 2016 · PubMed
Production of IL-27 in Multiple Sclerosis Lesions by Astrocytes and Myeloid Cells Sénécal V, Deblois G, Beauseigle D, et al. · Glia · 2016 · PubMed
Effects of Fumarates on Circulating and CNS Myeloid Cells in Multiple Sclerosis Michell-Robinson MA, Moore CS, Healy LM, et al. · Ann Clin Transl Neurol · 2016 · PubMed
2015
Proinflammatory GM-CSF-Producing B Cells in Multiple Sclerosis and B Cell Depletion Therapy Li R, Rezk A, Miyazaki Y, et al. · Sci Transl Med · 2015 · PubMed
Fetal Microglial Phenotype In Vitro Carries Memory of Prior In Vivo Exposure to Inflammation Cao M, Cortes M, Moore CS, et al. · Front Cell Neurosci · 2015 · PubMed
Roles of Microglia in Brain Development, Tissue Maintenance and Repair Michell-Robinson MA, Touil H, Healy LM, et al. · Brain · 2015 · PubMed
P2Y12 Expression and Function in Alternatively Activated Human Microglia Moore CS, Ase AR, Kinsara A, et al. · Neurol Neuroimmunol Neuroinflamm · 2015 · PubMed
Direct and Indirect Effects of Immune and CNS-Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation Moore CS, Cui QL, Warsi NM, et al. · J Immunol · 2015 · PubMed
2014
A Novel microRNA-132-Sirtuin-1 Axis Underlies Aberrant B-Cell Cytokine Regulation in Relapsing-Remitting MS Miyazaki Y, Li R, Rezk A, et al. · PLoS One · 2014 · PubMed
The Link Between Multiple Sclerosis and Depression Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C · Nat Rev Neurol · 2014 · PubMed
Identification of a Unique TGF-β-Dependent Molecular and Functional Signature in Microglia Butovsky O, Jedrychowski MP, Moore CS, et al. · Nat Neurosci · 2014 · PubMed
2013
Isolating, Culturing, and Polarizing Primary Human Adult and Fetal Microglia Durafourt BA, Moore CS, Blain M, Antel JP · Methods Mol Biol · 2013 · PubMed
Basis for Fluctuations in Lymphocyte Counts in Fingolimod-Treated Patients with MS Henault D, Galleguillos L, Moore C, et al. · Neurology · 2013 · PubMed
miR-155 as a Multiple Sclerosis-Relevant Regulator of Myeloid Cell Polarization Moore CS, Rao VT, Durafourt BA, et al. · Ann Neurol · 2013 · PubMed
Dual Effects of Daily FTY720 on Human Astrocytes In Vitro: Relevance for Neuroinflammation Wu C, Leong SY, Moore CS, et al. · J Neuroinflammation · 2013 · PubMed
MMP-3 Mediates Psychosine-Induced Globoid Cell Formation: Implications for Leukodystrophy Pathology Ijichi K, Brown GD, Moore CS, et al. · Glia · 2013 · PubMed
Over-Expression of X-Linked Inhibitor of Apoptosis Protein Modulates Neuronal Ca2+ Signaling Grant J, Parker K, Moore CS, et al. · Neurochem Res · 2013 · PubMed
2012
MicroRNA Dysregulation in Multiple Sclerosis de Faria O Jr, Moore CS, Kennedy TE, et al. · Front Genet · 2012 · PubMed
Stomatin Inhibits Pannexin-1-Mediated Whole-Cell Currents by Interacting with Its Carboxyl Terminal Zhan H, Moore CS, Chen B, et al. · PLoS One · 2012 · PubMed
Comparison of Polarization Properties of Human Adult Microglia and Blood-Derived Macrophages Durafourt BA, Moore CS, Zammit DA, et al. · Glia · 2012 · PubMed
An Alternate Perspective on the Roles of TIMPs and MMPs in Pathology Moore CS, Crocker SJ · Am J Pathol · 2012 · PubMed
2011
Astrocytic TIMP-1 Promotes Oligodendrocyte Differentiation and Enhances CNS Myelination Moore CS, Milner R, Nishiyama A, et al. · J Neurosci · 2011 · PubMed
How Factors Secreted from Astrocytes Impact Myelin Repair Moore CS, Abdullah SL, Brown A, Arulpragasam A, Crocker SJ · J Neurosci Res · 2011 · PubMed
Intravenous Administration of Human Embryonic Stem Cell-Derived Neural Precursor Cells Attenuates CNS Demyelination Crocker SJ, Bajpai R, Moore CS, et al. · Neuropathol Appl Neurobiol · 2011 · PubMed
2010
Effects of IFN-B on TRAIL and Decoy Receptor Expression in MS Patients Hebb AL, Moore CS, Bhan V, Robertson GS · Autoimmune Dis · 2010 · PubMed
Human Kallikrein 6 Cerebrospinal Levels Are Elevated in Multiple Sclerosis Hebb AL, Bhan V, Wishart AD, Moore CS, Robertson GS · Curr Drug Discov Technol · 2010 · PubMed
Over-Expression of XIAP Slows Presbycusis in C57BL/6J Mice Wang J, Menchenton T, Yin S, et al. · Neurobiol Aging · 2010 · PubMed
2009
Lack of TIMP-1 Increases Severity of Experimental Autoimmune Encephalomyelitis Thorne M, Moore CS, Robertson GS · J Neuroimmunol · 2009 · PubMed
Elevated ATG5 Expression in Autoimmune Demyelination and Multiple Sclerosis Alirezaei M, Fox HS, Flynn CT, Moore CS, et al. · Autophagy · 2009 · PubMed
2008
Increased XIAP Expression Exacerbates Experimental Autoimmune Encephalomyelitis Moore CS, Hebb AL, Blanchard MM, et al. · J Neuroimmunol · 2008 · PubMed
Expression of the Inhibitor of Apoptosis Protein Family in Multiple Sclerosis Hebb AL, Moore CS, Bhan V, et al. · Mult Scler · 2008 · PubMed
Targeting Apoptosis to Treat Multiple Sclerosis Hebb AL, Moore CS, Bhan V, Robertson GS · Curr Drug Discov Technol · 2008 · PubMed
Inhibitor of Apoptosis Protein Profiling in EAE Implicates Increased XIAP in T Lymphocytes Moore CS, Hebb AL, Robertson GS · J Neuroimmunol · 2008 · PubMed
2007
X-Linked Inhibitor of Apoptosis Regulates T Cell Effector Function Zehntner SP, Bourbonnière L, Moore CS, et al. · J Immunol · 2007 · PubMed
2006
Neuroanatomical and Pharmacological Assessment of Fos Expression Induced by Phosphodiesterase-4 Inhibitor Bureau Y, Handa M, Zhu Y, et al. · Neuropharmacology · 2006 · PubMed
Peripheral Phosphodiesterase 4 Inhibition Prevents Experimental Autoimmune Encephalomyelitis Moore CS, Earl N, Frenette R, et al. · J Pharmacol Exp Ther · 2006 · PubMed